Dr Alison Cross BSc, PhD, FHEA
Senior Lecturer
Summary
Alison was appointed as a lecturer at Ï㽶ÊÓƵ following a PhD in neuroimmunology, and six years post-doctoral research in Neuroscience at Ï㽶ÊÓƵ. Her specialist teaching areas related to her research are immunology and neurological disease and she also teaches a wide range of biological subjects. Her research focuses on the pathogenesis of multiple sclerosis and stroke.
Teaching
School of Biosciences and Chemistry
College of Health, Wellbeing and Life Sciences
Extended degree, BSc Biosciences Programme and MSc Biosciences Programme
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Dr Stuart Allen, University of Manchester
Dr David Buttle, Sheffield University
Dr Kirsty Harkness
Royal Hallamshire Hospital, Sheffield
Publications
Journal articles
Hanson, F., Ribeiro de Oliveira, M., Cross, A., Allen, L., & Campbell, S. (2024). . iScience, 27 (9).
Binch, A.L.A., Cole, A.A., Breakwell, L.M., Michael, A.L.R., Chiverton, N., Creemers, L.B., ... Le Maitre, C. (2015). . Arthritis research & therapy, 17 (1), 370.
Phillips, K.L.E., Cullen, K., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., ... Le Maitre, C.L. (2015). . Osteoarthritis and Cartilage, 23 (7), 1165-1177.
Binch, A.L.A., Cole, A.A., Breakwell, L.M., Michael, A.L.R., Chiverton, N., Creemers, L.B., ... Le Maitre, C. (2015). . Oncotarget, 6 (21), 18338-18354.
Binch, A.L.A., Cole, A.A., Breakwell, L.M., Michael, A., Chiverton, N., Cross, A.K., & Le Maitre, C.L. (2014). . Arthritis research & therapy, 16 (5), 416.
LA Binch, A., Cole, A.A., Breakwell, L.M., Michael, A.L.R., Chiverton, N., Cross, A.K., & Le Maitre, C. (2014). . Arthritis Ï㽶ÊÓƵ and Therapy, 16.
Bradford, C.M., Ramos, I., Cross, A.K., Haddock, G., McQuaid, S., Nicholas, A.P., & Woodroofe, M.N. (2014). . Journal of Neuroimmunology, 273 (1-2), 85-95.
Binch, A., Cross, A., & Le Maitre, C. (2014). . OA Arthritis, 2 (1), 4.
Wang, J., Tian, Y., Phillips, K.L.E., Chiverton, N., Haddock, G., Bunning, R., ... Risbud, M.V. (2013). . Arthritis & rheumatism, 65 (3), 832-842.
Phillips, K.L.E., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., Haddock, G., ... Le Maitre, C.L. (2013). . Arthritis research & therapy, 15 (6), R213.
Wang, H., Tian, Y., Wang, J., Phillips, K.L.E., Binch, A.L.A., Dunn, S., ... Risbud, M.V. (2013). . The Journal of biological chemistry, 288 (23), 16761-74.
Frentzou, G., Bradford, C., Harkness, K.A., Haddock, G., Woodroofe, N.W., & Cross, A. (2012). . Journal of Molecular Neuroscience, 46 (2), 343-351.
Bradford, C.M., Cross, A., Haddock, G., Woodroofe, N.W., & Sharrack, B. (2011). . Future Neurology, 6 (4), 521-530.
Reid, M.J., Cross, A.K., Haddock, G., Allan, S.M., Stock, C.J., Woodroofe, M.N., ... Bunning, R.A.D. (2009). . Neuroscience letters, 452 (3), 252-257.
Bradford, C.M., Cross, A.K., Haddock, G., & Woodroofe, M.N. (2009). . British journal of neuroscience nursing, 5 (1), 1-13.
Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J.T., Bunning, R.A., ... Woodroofe, M.N. (2007). . Biochemical Society Transactions, 35 (4), 692.
Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., ... Woodroofe, N. (2006). . Brain research, 1088 (1), 19-30.
Cross, A.K., Haddock, G., Surr, J., Plumb, J., Buttle, D.J., & Woodroofe, N. (2005). . Journal of autoimmunity, 26 (1), 16-23.
Haddock, G., Cross, A.K., Plumb, J., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2005). . Multiple Sclerosis, 12 (4), 386-396.
Plumb, J., McQuaid, S., Cross, A.K., Surr, J., Haddock, G., Bunning, R.A.D., & Woodroofe, M.N. (2005). . Multiple Sclerosis, 12 (4), 375-385.
Plumb, J., Cross, A.K., Surr, J., Haddock, G., Smith, T., Bunning, R.A.D., & Woodroofe, M.N. (2005). ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 164 (1-2), 1-9.
Cross, A.K., & Woodroofe, M.N. (2001). Immunoregulation of microglial functional properties. Microscopy research and technique, 54 (1), 10-17.
Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. Glia, 28 (3), 183-189. http://doi.org/10.1002/(sici)1098-1136(199912)28:3<183::aid-glia2>3.0.co;2-3
Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. Glia, 28 (3), 183-189. http://doi.org/10.1002/(sici)1098-1136(199912)28:3<183::aid-glia2>3.0.co;2-3
Woodroofe, N., Cross, A.K., Harkness, K., & Simpson, J.E. (1999). The role of chemokines in the pathogenesis of multiple sclerosis. Advances in experimental medicine and biology, 468, 135-150.
Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. Journal of neuroscience research, 55 (1), 17-23. http://doi.org/10.1002/(sici)1097-4547(19990101)55:1<17::aid-jnr3>3.0.co;2-j
Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. Journal of Neuroscience Ï㽶ÊÓƵ, 55 (1), 17-23. http://doi.org/10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3>3.0.CO;2-J
Cross, A.K., Richardson, V., Ali, S.A., Palmer, I., Taub, D.D., & Rees, R.C. (1997). MIGRATION RESPONSES OF HUMAN MONOCYTIC CELL LINES TO α- AND β-CHEMOKINES. Cytokine, 9 (7), 521-528.
Conference papers
Abuneeza, E., Cross, A., Haddock, G., Bunning, R., & Woodroofe, N. (2014). . Journal of Neuroimmunology, 275 (1-2), 131-132.
Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Interleukin-1 Regulates Chemokine Expression in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.
Estevao, A.C.B., Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., ... Le Maitre, C.L. (2012). CXCL1, CXCL2 and CXCL3 in the Pathogenesis of Intervertebral Disc Degeneration. JOURNAL OF PATHOLOGY, 228, S30.
Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Chemokines and their Receptors in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.
Gibrel, G., Cross, A.K., Haddock, G., Buttle, D.J., & Bunning, R.A.D. (2012). The role of ADAMTSs and versican cleavage in multiple sclerosis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 93 (4), A11.
Phillips, K.L.E., Chiverton, N., Bunning, R.D., Haddock, G., Cross, A.K., & Le Maitre, C.L. (2012). CYTOKINE AND CHEMOKINE EXPRESSION PROFILE IN HUMAN INTERVERTEBRAL DISC DEGENERATION. RHEUMATOLOGY, 51, 147.
Bradford, C.M. (2012). .
Gibrel, G., Cross, A.K., Haddock, G., Buttle, D.J., & Bunning, R.A.D. (2011). The expression and modulation of ADAMTS-1 and TIMP-3 in neuronal SHSY-5Y cells and CNS tissue. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 92 (3), A13.
Frentzou, G.A., Kamara, C., Harkness, K.A., Haddock, G., Doyle, C., Taylor, M., ... Randall, M. (2010). POS07 Reduced ADAMTS-13 activity levels in partial anterior circulation transient ischaemic attack patients compared to nonstroke controls. Journal of Neurology, Neurosurgery & Psychiatry, 81 (11), e69.
Haddock, G., Cross, A.K., Allan, S., Bunning, R.A.D., Buttle, D.J., & Woodroofe, M.N. (2007). Changes in brain expression of chondroitin sulphate proteoglycans following transient middle cerebral artery occlusion in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 88 (6), A92.
Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J., Bunning, R.A.D., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692-694.
Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A.D., ... Woodroofe, M.N. (2006). ADAMTS-1 and-4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by cytokines in astrocytes and endothelial cell cultures. JOURNAL OF NEUROIMMUNOLOGY, 178, 249.
Reid, M.J., Allan, S., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2006). ADAMTS-9 is upregulated at the mRNA level following middle cerebral artery occlusion in rats. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 87 (1), A28.
Reid, M.J., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2005). Pro-inflammatory cytokines modulate a disintegrin and metalloproteinase domain with thrombospondin motif S-9 mRNA expression in human glial cell lines. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 86 (6), A81-A82.
Haddock, G., Cross, A.K., Bunning, R.A.D., Plumb, J., Surr, J., Buttle, D.J., ... Woodroofe, M.N. (2004). Expression of ADAMTS-1, -4 -5 and TIMP-3 in different stages of experimental autoimmune encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 58.
Haddock, G., Cross, A.K., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Expression of ADAMTS-1,-4-5 and TIMP-3 in central nervous system cell lines: Possible role in CNS physiology and pathology. GLIA, 33.
Book chapters
Bradford, C., Nicholas, A.P., Cross, A.K., & Woodroofe, N. (2013). . In Nicholas, A.P., & Bhattacharya, S.K. (Eds.) Protein deimination in human health and disease. (pp. 165-185). Springer:
Theses / Dissertations
Abuneeza, E. (2015). . (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., Cross, A., & Haddock, G.
Phillips, K. (2013). . (Doctoral thesis). Supervised by Le Maitre, C., Cross, A., Bunning, R., & Haddock, G.
Gibrel, G.G.F. (2012). . (Doctoral thesis). Supervised by Bunning, R., Cross, A., Haddock, G., & Buttle, D.
Presentations
Hanson, F., Cross, A., Allen, K.E., & Campbell, S. (2022). A cell type specific role for eIF2B localisation in controlling cellular response to acute and chronic stress. Presented at: Translation UK, Ï㽶ÊÓƵ
Oliveira, M., Cross, A., Campbell, S., & Allen, K.E. (2022). The role of eIF2BÉ‘ in the integrity of eIF2B bodies in glial and neuronal cells. Presented at: Translation IK, Sheffeld Hallam University
Posters
Campbell, S., Oliveira, M., Cross, A., & Allen, K.E. (2022). The role of eIF2BÉ‘ in the integrity of eIF2B bodies in glial and neuronal cells. Presented at: Translational Control, Cold Spring Harbor Laboratories
Hanson, F., Allen, K.E., Cross, A., & Campbell, S. (2022). eIF2B localisation is regulated in a cell type specific manner during acute and chronic activity of the integrated stress response. Presented at: Translational Control, Cold Spring Harbor Laboratories
Oliveira, M., Campbell, S., Cross, A., & Allen, K.E. (2022). The role of eIF2BÉ‘ in the integrity of eIF2B bodies in glial and neuronal cells. Presented at: Translation UK, Ï㽶ÊÓƵ
Campbell, S., Hanson, F., Cross, A., Allen, K.E., & Campbell, S. (2021). Differential eIF2B-mediated translation control in neuronal and glial cells. Presented at: Protein Synthesis and Translational Control, Virtual EMBL conference
Hanson, F., Cross, A., Allen, K.E., & Campbell, S. (2021). Differential eIF2B-mediated translation control in neuronal and glial cells. Presented at: Translation UK, Virtual conference
Oliveira, M., Cross, A., Campbell, S., & Allen, K.E. (2021). B-cell epitope prediction and Immunocytochemistry methodology for eIF2B detection in astrocytes. Presented at: Translation UK, Virtual conference
Hanson, F., Cross, A., Allen, K., & Campbell, S. (2020). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Cold Spring Harbor meeting: Translational Control (Virtual), Cold Spring Harbor Laboratories
Hanson, F., Allen, K., Cross, A., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: XIV European Meeting on Glial Cells in Health and Disease, Porto, Portugal
Hanson, F., Cross, A., Allen, K., & Campbell, S. (2019). Investigating the role of the delta (δ) subunit of eIF2B during stress and disease. Presented at: Translation UK, University of Glasgow
Hodgson, R., Allen, K., Cross, A., & Campbell, S. (2019). The impact of eIF2B mutations and ISR-modifying drugs on eIF2B localisation. Presented at: Translation UK, University of Glasgow
Postgraduate supervision
The Role Of ADAMTS-1, 4 and 9 in Multiple Sclerosis (MS)
Cytokine regulation of innervation and vascularisation in human intervertebral disc degeneration
The role of citrullination of CNS proteins in multiple sclerosis.
Cytokines and chemokines in the pathogenesis of low back pain
The role of ADAMTS-1, 4, 5, 9 and ADAM-17 in multiple sclerosis