Dr Gail Haddock BSc, PhD, FHEA
Senior Lecturer
Summary
I was appointed as a lecturer at Ï㽶ÊÓƵ after completing a PhD, followed by a 5-year postdoctoral position in neuroscience at Ï㽶ÊÓƵ. I teach a wide range of subjects including anatomy and physiology, cell biology and biochemistry. My main research area is neuroimmunology with a specific interest in multiple sclerosis.
About
I was appointed initially at Ï㽶ÊÓƵ as a research technician, during which time I studied for a PhD part time. I then worked as a postdoctoral researcher for 5 years. My work was investigating the role of the ADAMTSs in multiple sclerosis from which I published several research papers and presented my work at national and international conferences. I was then appointed a lecturer at Ï㽶ÊÓƵ.
Cell Biology/Biochemistry
Neuroscience
Teaching
Cells and molecules, organs and systems, biomedical investigative techniques, biology of disease, PSP 2 and undergraduate and postgraduate projects
Ï㽶ÊÓƵ
Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the central nervous system (CNS) affecting mainly white matter. Key events in the pathogenesis of MS include breakdown of the blood-brain barrier, resulting in infiltration of inflammatory cells leading (directly or indirectly) to changes in the composition of the ECM. The extracellular matrix proteins are important to brain structure through maintenance of the correct hydrodynamics and in their interactions with other ECM components.The sequence of events leading to changes in the ECM of white matter in MS are not known, nor are the enzymes that are responsible for these processes which ultimately lead to axonal loss. Alterations in turnover of the ECM contribute to disease processes and are modulated by injury. ADAMTS-1, -4 and -5 have been shown to cleave aggregating chondroitin sulphate proteoglycans (CSPGs) such as aggrecan, versican and brevican which are key components of CNS ECM. We wish to investigate the roles played in this process by the ADAMTS group.
Collaborators:
Dr Stuart Allen, University of Manchester
Dr David Buttle, University of Sheffield
Publications
Journal articles
Lawton, M., Haddock, G., Conroy, P., & Sage, K. (2016). . Archives of Physical Medicine and Rehabilitation, 97 (11), 1979-1993.
Phillips, K.L.E., Cullen, K., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., ... Le Maitre, C.L. (2015). . Osteoarthritis and Cartilage, 23 (7), 1165-1177.
Bradford, C.M., Ramos, I., Cross, A.K., Haddock, G., McQuaid, S., Nicholas, A.P., & Woodroofe, M.N. (2014). . Journal of Neuroimmunology, 273 (1-2), 85-95.
Wang, J., Tian, Y., Phillips, K.L.E., Chiverton, N., Haddock, G., Bunning, R., ... Risbud, M.V. (2013). . Arthritis & rheumatism, 65 (3), 832-842.
Phillips, K.L.E., Chiverton, N., Michael, A.L.R., Cole, A.A., Breakwell, L.M., Haddock, G., ... Le Maitre, C.L. (2013). . Arthritis research & therapy, 15 (6), R213.
Hadjivassiliou, M., Aeschlimann, P., Sanders, D.S., Mäki, M., Kaukinen, K., Grünewald, R.A., ... Aeschlimann, D.P. (2013). Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurology, 80 (19), 1740-1745.
Frentzou, G., Bradford, C., Harkness, K.A., Haddock, G., Woodroofe, N.W., & Cross, A. (2012). . Journal of Molecular Neuroscience, 46 (2), 343-351.
Bradford, C.M., Cross, A., Haddock, G., Woodroofe, N.W., & Sharrack, B. (2011). . Future Neurology, 6 (4), 521-530.
Reid, M.J., Cross, A.K., Haddock, G., Allan, S.M., Stock, C.J., Woodroofe, M.N., ... Bunning, R.A.D. (2009). . Neuroscience letters, 452 (3), 252-257.
Bradford, C.M., Cross, A.K., Haddock, G., & Woodroofe, M.N. (2009). . British journal of neuroscience nursing, 5 (1), 1-13.
Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J.T., Bunning, R.A., ... Woodroofe, M.N. (2007). . Biochemical Society Transactions, 35 (4), 692.
Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., ... Woodroofe, N. (2006). . Brain research, 1088 (1), 19-30.
Cross, A.K., Haddock, G., Surr, J., Plumb, J., Buttle, D.J., & Woodroofe, N. (2005). . Journal of autoimmunity, 26 (1), 16-23.
Haddock, G., Cross, A.K., Plumb, J., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2005). . Multiple Sclerosis, 12 (4), 386-396.
Plumb, J., McQuaid, S., Cross, A.K., Surr, J., Haddock, G., Bunning, R.A.D., & Woodroofe, M.N. (2005). . Multiple Sclerosis, 12 (4), 375-385.
Plumb, J., Cross, A.K., Surr, J., Haddock, G., Smith, T., Bunning, R.A.D., & Woodroofe, M.N. (2005). ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 164 (1-2), 1-9.
Conference papers
Abuneeza, E., Cross, A., Haddock, G., Bunning, R., & Woodroofe, N. (2014). . Journal of Neuroimmunology, 275 (1-2), 131-132.
Abuneeza, E., Bunning, R., Cross, A., Haddock, G., & Woodroofe, N. (2013). Changes in extracellular matrix chondroitin sulphate proteoglycans in multiple sclerosis white matter lesions: a role for ADAMTS-9. IMMUNOLOGY, 140, 128.
Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Interleukin-1 Regulates Chemokine Expression in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.
Phillips, K.L.E., Chiverton, N., Cole, A., Michael, A., Breakwell, L., Haddock, G., ... Le Maitre, C.L. (2012). Chemokines and their Receptors in the Human Intervertebral Disc. JOURNAL OF PATHOLOGY, 228, S30.
Gibrel, G., Cross, A.K., Haddock, G., Buttle, D.J., & Bunning, R.A.D. (2012). The role of ADAMTSs and versican cleavage in multiple sclerosis. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 93 (4), A11.
Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J., Bunning, R.A.D., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692-694.
Haddock, G., Cross, A.K., Bunning, R.A.D., Plumb, J., Surr, J., Buttle, D.J., ... Woodroofe, M.N. (2004). Expression of ADAMTS-1, -4 -5 and TIMP-3 in different stages of experimental autoimmune encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 58.
Plumb, J., Bunning, R., Cross, A., Surr, J., Haddock, G., Smith, T., & Woodroofe, N. (2004). ADAM-17 expression in spinal cord white matter of Lewis rats with EAE. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 116.
Cross, A., Haddock, G., Surr, J., Bunning, R.A.D., Buttle, D., Romero, J., & Woodroofe, N.M. (2004). Expression of ADANITS-1, 4, -5 and TIMP-3 in a primary human astrocyte cell line: possible role in CNS physiology and pathology. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 121.
Haddock, G., Cross, A.K., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Expression of ADAMTS-1,-4-5 and TIMP-3 in central nervous system cell lines: Possible role in CNS physiology and pathology. GLIA, 33.
Lassmann, H. (1995). Oligodendrocytes in eae and multiple sclerosis. Journal of Neuroimmunology, 63 (1), 97.
Theses / Dissertations
Liaskos, M. (2016). . (Doctoral thesis). Supervised by Mckay, N., Lawson, K., & Haddock, G.
Abuneeza, E. (2015). . (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., Cross, A., & Haddock, G.
Phillips, K. (2013). . (Doctoral thesis). Supervised by Le Maitre, C., Cross, A., Bunning, R., & Haddock, G.
Gibrel, G.G.F. (2012). . (Doctoral thesis). Supervised by Bunning, R., Cross, A., Haddock, G., & Buttle, D.
Postgraduate supervision
The Role Of ADAMTS-1, 4 and 9 in Multiple Sclerosis (MS)
The Role of the Urothelial Mucosa In Bladder Mechanosensation
Investigating the role of citrullination, a post translational modification, of CNS proteins on the disease pathogenesis and whether antibodies in the serum and/or cerebrospinal fluid may provide a diagnostic indicator of multiple sclerosis.
The role of ADAMTS-1, -4 and -5 in multiple sclerosis