Dr Keith Miller BSc, PhD, FHEA
Senior Lecturer of Medical Microbiology
Summary
Keith was appointed as a lecturer at Ï㽶ÊÓƵ after completing a BSc and a PhD in Medical Microbiology at the University of Leeds. Also at the University of Leeds, he completed three post-doctoral research fellowships funded by the Department of Health, Novartis and the MRC. During his teaching career at Sheffield Hallam he has taught microbiology and biochemistry and is the former course leader for MSc Biomedical Sciences, MSc Biomedical Laboratory Sciences and MSc Molecular Microbiology. He is a Fellow of the Higher Education Academy and a member of both the American Society for Microbiology and the British Society for Antimicrobial Chemotherapy.
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Keith's research group is interested in all areas of antimicrobial chemotherapy research. We are investigating new sources of antimicrobial agents including snake and scorpion venom, deep sea corals and novel synthetic drug scaffolds. We are trying to identify and characterise the interactions between drugs and their targets at a molecular level. We are researching genetic, proteomic and biophysical mechanisms of antimicrobial resistance found here in the UK and in the developing world. We are also developing novel cell-based biosensors for the rapid detection of sepsis-causing pathogens.
Publications
Journal articles
Bertelsen, M., Lacey, M., Nichol, T., & Miller, K. (2023). . Pharmaceutics, 15 (10).
Rawson, K.M., Lacey, M.M., Strong, P.N., & Miller, K. (2022). . International Journal of Molecular Sciences, 23 (14).
Elrayess, R.A., Mohallal, M.E., Mobarak, Y.M., Ebaid, H.M., Haywood-Small, S., Miller, K., ... Abdel-Rahman, M.A. (2022). . Frontiers in Pharmacology, 12.
Khan, M., Miller, K., Rawson, K., & Zhou, Y. (2021). . Advances in Biological Chemistry, 11 (5), 251-265.
Tawfik, M.M., Bertelsen, M., Abdel-Rahman, M.A., Strong, P.N., & Miller, K. (2021). . mSphere, 6 (3).
Elrayess, R.A., Mohallal, M.E., El-Shahat, Y.M., Ebaid, H.M., Miller, K., Strong, P., & Abdel-Rahman, M.A. (2019). . International Journal of Peptide Ï㽶ÊÓƵ and Therapeutics, 26 (3), 1409-1415.
Codjoe, F.S., Brown, C.A., Smith, T., Miller, K., & Donkor, E.S. (2019). . PLoS One, 14 (9), e0222168.
Codjoe, F.S., Donkor, E.S., Smith, T., & Miller, K. (2019). . Microbial drug resist.
Bao, P., Paterson, D.A., Harrison, P.L., Miller, K., Peyman, S., Jones, J.C., ... Gleeson, H.F. (2019). . Lab on a chip, 19 (6), 1082-1089.
Heath, G.R., Harrison, P., Strong, P., Evans, S.D., & Miller, K. (2018). . Soft Matter, 14 (29), 6146-6154.
Chirila, P., Skibinski, L., Miller, K., Hamilton, A., & Whiteoak, C. (2018). . Advanced Synthesis & Catalysis, 360 (12), 2324-2332.
Liu, G., Yang, F., Li, F., Li, Z., Lang, Y., Shen, B., ... Cao, Z. (2018). . Frontiers in Microbiology, 9, 1159.
Harrison, P.L., Abdel-Rahman, M.A., Strong, P., Tawfik, M.M., & Miller, K. (2016). . Toxicon, 117, 30-36.
Harrison, P.L., Heath, G.R., Johnson, B.R.G., Abdel-Rahman, M.A., Strong, P., Evans, S.D., & Miller, K. (2016). . Biochimica et Biophysica Acta (BBA) - Biomembranes, 1858 (11), 2737-2744.
Harrison, P.L., Abdel-Rahman, M., Miller, K., & Strong, P. (2014). . Toxicon, 88, 115-137.
Khan, A., Miller, K., Rainsford, K., & Zhou, Y. (2013). . Molecules, 18 (3), 3227-3240.
Miller, K., Dunsmore, C.J., Leeds, J.A., Patching, S.G., Sachdeva, M., Blake, K.L., ... Chopra, I. (2010). . Journal of Antimicrobial Chemotherapy, 65 (12), 2566-2573.
Mariner, K.R., Trowbridge, R., Agarwal, A.K., Miller, K., O'Neill, A.J., Fishwick, C.W., & Chopra, I. (2010). . Antimicrobial Agents and Chemotherapy, 54 (10), 4506-4509.
Ooi, N., Miller, K., Randall, C., Rhys-Williams, W., Love, W., & Chopra, I. (2010). . Journal of Antimicrobial Chemotherapy, 65 (1), 72-78.
Ooi, N., Miller, K., Hobbs, J., Rhys-Williams, W., Love, W., & Chopra, I. (2009). . Journal of Antimicrobial Chemotherapy, 64 (4), 735-740.
Hobbs, J.K., Miller, K., O'Neill, A.J., & Chopra, I. (2008). . Journal of Antimicrobial Chemotherapy, 62 (5), 1003-1008.
Dunsmore, C.J., Miller, K., Blake, K.L., Patching, S.G., Henderson, P.J.F., Garnett, J.A., ... Angeles, J.D.L. (2008). . Bioorganic & Medicinal Chemistry Letters, 18 (5), 1730-1734.
Miller, K., O'Neill, A.J., Wilcox, M.H., Ingham, E., & Chopra, I. (2008). . Antimicrobial Agents and Chemotherapy, 52 (6), 1940-1944.
Chopra, I., Schofield, C., Everett, M., ONeill, A., Miller, K., Wilcox, M., ... Courvalin, P. (2008). . The Lancet Infectious Diseases, 8 (2), 133-139.
Driffield, K., Miller, K., Bostock, J.M., O'Neill, A.J., & Chopra, I. (2008). . Journal of Antimicrobial Chemotherapy, 61 (5), 1053-1056.
Miller, K., Dunsmore, C.J., Fishwick, C.W.G., & Chopra, I. (2008). . Antimicrobial Agents and Chemotherapy, 52 (5), 1737-1742.
Driffield, K.L., Bostock, J.M., Miller, K., O'neill, A.J., Hobbs, J.K., & Chopra, I. (2006). . The Journal of antimicrobial chemotherapy, 58 (4), 905-907.
Miller, K., Storey, C., Stubbings, W.J., Hoyle, A.M., Hobbs, J.K., & Chopra, I. (2005). . The Journal of antimicrobial chemotherapy, 55 (4), 579-582.
O'Neill, A.J., Miller, K., Oliva, B., & Chopra, I. (2004). Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus. The Journal of antimicrobial chemotherapy, 54 (6), 1127-1129.
Oliva, B., O'Neill, A.J., Miller, K., Stubbings, W., & Chopra, I. (2004). Anti-staphylococcal activity and mode of action of clofazimine. The Journal of antimicrobial chemotherapy, 53 (3), 435-440.
Miller, K., O'Neill, A.J., & Chopra, I. (2004). . Antimicrobial agents and chemotherapy, 48 (1), 23-29.
Chopra, I., O'Neill, A.J., & Miller, K. (2003). . Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 6 (3), 137-145.
Bostock, J.M., Miller, K., O'Neill, A.J., & Chopra, I. (2003). Zeocin resistance suppresses mutation in hypermutable Escherichia coli. Microbiology (Reading, England), 149 (Pt 4), 815-816.
Oliva, B., Miller, K., Caggiano, N., O'Neill, A.J., Cuny, G.D., Hoemann, M.Z., ... Chopra, I. (2003). Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrobial agents and chemotherapy, 47 (2), 458-466.
Miller, K., O'Neill, A.J., & Chopra, I. (2002). . The Journal of antimicrobial chemotherapy, 49 (6), 925-934.
Theses / Dissertations
Slater, J.E. (2024). . (Doctoral thesis). Supervised by Allwood, D., Hamilton, A., & Miller, K.
Chirila, P.G. (2021). . (Doctoral thesis). Supervised by Whiteoak, C., Hamilton, A., & Miller, K.
Freeman-Parry, L.E. (2020). . (Doctoral thesis). Supervised by Miller, K., & Strong, P.
Elzayat, M.T. (2017). . (Doctoral thesis). Supervised by Miller, K., & Strong, P.
Codjoe, F.S. (2016). . (Doctoral thesis). Supervised by Miller, K., & Smith, T.
Harrison, P.L. (2014). . (Doctoral thesis). Supervised by Miller, K., & Strong, P.
Postgraduate supervision
01/10/2010 - 30/06/2018: Louise Freeman-Parry - Antimicrobial properties of wound dressings
05/10/2015 - 04/10/2019: Kirstie Rawson - Antimicrobial peptides from venom: structure, function & toxicity
Previous supervision:
2017: Biocidal properties of wound dressings
2017: Detection and molecular characterisation of carbapenem-resistant Gram-negative bacilli infections in selected hospitals in Ghana
2017: Characterisation of novel antimicrobial peptides and other molecules from Egyptian scorpion and snake venoms
2016: Investigating marine derived natural product scaffold: semi-synthetic and biological studies
2014: Identification and characterisation of antimicrobials from snake and scorpion venoms and haemolymph