Dr Lewis Quayle BSc (Hons), MRes, PhD, FHEA
Senior Lecturer in Data Science and Analytics
Summary
Lewis is a bioinformatician and data scientist with a strong interdisciplinary background, having transitioned from laboratory-based cancer cell biology to computational biology and healthcare data analytics during his postdoctoral work. He possesses extensive expertise across diverse data science and bioinformatics workflows, including high-performance computing pipeline development, microarray and next-generation sequencing (NGS) data processing, large-scale clinical data analysis, machine learning (both supervised and unsupervised), text mining, topic modelling and sentiment analysis, graph network analytics, and spatial data analysis.
Passionate about education, Lewis is dedicated to equipping the next generation of data scientists with analytical skills while remaining deeply research-active. He is a member of two working groups within the Genomics England 100,000 Genomes Project and collaborates on numerous clinical, fundamental, and digital healthcare research projects. His current work involves genomic and clinical data analysis and predictive modelling in the areas of bladder cancer, ovarian cancer, colorectal cancer, breast cancer, and gestational trophoblastic disease.
About
Lewis is a Senior Lecturer in Data Science and Analytics in the Department of Computing, appointed in May 2023, with a distinguished academic and research career spanning oncology, bioinformatics, and data science. He completed his PhD in October 2017 at the Department of Oncology & Metabolism, University of Sheffield Medical School, where his research focused on developing innovative models of mitotic quiescence in human breast cancer. His early postdoctoral work expanded on this by characterising cancer cell populations from these models through advanced techniques such as next-generation sequencing (NGS) and bioinformatic analytics.
In 2019, Lewis broadened his expertise with a three-month training placement in high-performance computing at the Kinghorn Centre for Clinical Genomics in Sydney, Australia. Subsequently, he held a two-year position as a postdoctoral cancer bioinformatician, continuing his cutting-edge breast cancer research. In June 2022, he joined the Sheffield Bioinformatics Core Facility as a cancer bioinformatician, contributing to both pre-clinical and clinical projects involving large-scale NGS and clinical data analysis.
Lewis has been deeply engaged in education throughout his career, beginning during his MRes and continuing through his PhD and postdoctoral tenure. He has supervised numerous undergraduate, BMedSci, MSc and MRes, and PhD research projects and has lectured extensively on topics including NGS, bioinformatics, and computational research best practices. His past teaching contributions include the MSc Translational Oncology and MSc Molecular Medicine programmes at the University of Sheffield, and Lewis holds a three-year honorary post as Senior Lecturer in Bioinformatics in the Department of Oncology & Metabolism at the University of Sheffield. His dedication to excellence in teaching and adherence to the Professional Standards Framework (2023) have earned him Fellowship of Advance HE (FHEA). Additionally, he is certified by The Carpentries to deliver foundational coding and data science skills through their Data Carpentry, Library Carpentry, and Software Carpentry curriculums.
Teaching
School of Computing and Digital Technologies
College of Business, Technology and Engineering
Subject area
Digital Analytics and Technologies
Courses
MSc Big Data Analytics
MSc Healthcare Analytics and Artificial Intelligence
Modules
Learning Systems and Data Analysis for Healthcare
Ethics of Healthcare Information
Advanced Data Management Project
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Lewis is actively engaged in research across his areas of expertise, with projects spanning multiple human cancers. He is a member of two Genomics England 100,000 Genomes Project working groups, contributing to the creation of mutational maps for bladder and ovarian cancer cohorts. Additionally, he serves as a member of the bioinformatics team for the GUSTO Phase II clinical trial and as a co-investigator on projects focused on several critical areas of cancer research. These include developing a predictive test for chemotherapy response in gestational trophoblastic disease and continuing his postdoctoral work to identify molecular drivers and biomarkers of metastatic dormancy in breast cancer.
Beyond these major initiatives, Lewis contributes to various clinical and foundational research projects, exploring next-generation sequencing, high-throughput screening, public healthcare data analytics, and predictive modelling of prognostic risk factors across diverse settings. His work exemplifies a commitment to leveraging bioinformatics and data science to advance cancer research and improve patient outcomes.
Publications
Journal articles
Morita, M., Arshad, F., Quayle, L., George, C.N., Lefley, D.V., Kalajzic, I., ... Ottewell, P.D. (2024). . Bone Reports.
Griffin, J., Down, J., Quayle, L., Heath, P.R., Gibb, E.A., Davicioni, E., ... Catto, J.W.F. (2024). . The Journal of Pathology: Clinical Ï㽶ÊÓƵ, 10 (2).
Catto, J.W.F., Mandrik, O., Quayle, L.A., Hussain, S.A., McGrath, J., Cresswell, J., ... Cumberbatch, M. (2023). . BJU international, 131 (6), 734-744.
Quayle, L.A., Spicer, A., Ottewell, P.D., & Holen, I. (2021). . Cancers, 13 (16).
Tulotta, C., Lefley, D.V., Moore, C.K., Amariutei, A.E., Spicer-Hadlington, A.R., Quayle, L.A., ... Ottewell, P.D. (2021). . npj breast cancer, 7 (1).
Quayle, L.A., Ottewell, P.D., & Holen, I. (2018). . Clinical & experimental metastasis, 35 (8), 831-846.
Quayle, L., Ottewell, P., & Holen, I. (2018). . Breast Cancer Ï㽶ÊÓƵ and Treatment, 167 (1), 393-394.
Quayle, L.A., Pereira, M.G., Scheper, G., Wiltshire, T., Peake, R.E., Hussain, I., ... Bates, T.E. (2017). . Oncotarget, 8 (51), 88670-88688.
Quayle, L., Park, S., McDonnell, D.P., Ottewell, P.D., & Holen, I. (2017). . Cancer Ï㽶ÊÓƵ, 77 (4_Supp).
Quayle, L., Ottewell, P.D., & Holen, I. (2015). Bone Metastasis: Molecular Mechanisms Implicated in Tumour Cell Dormancy in Breast and Prostate Cancer. Current cancer drug targets, 15 (6), 469-480.
Conference papers
Crabb, S., Hussain, S., Oughton, J., Swain, J., Cairns, D., Collinson, M., ... Catto, J. (2024). . Journal of Clinical Oncology, 42 (16 sup).
Griffin, J., Down, J., Quayle, L., Heath, P., & Catto, J. (2023). . The Journal of Pathology, 261 (S1).
Quayle, L., Ottewell, P., & Holen, I. (2018). . Breast Cancer Ï㽶ÊÓƵ and Treatment, 167, 309-405.
Quayle, L., Park, S.H., McDonnell, D., Ottewell, P., & Holen, I. (2017). . Cancer Ï㽶ÊÓƵ, 77 (4 supp).
Book chapters
Holen, I., & Quayle, L. (2021). Stem cell niches in bone and their roles in cancer metastasis. In Advances in Stem Cells and their Niches. (pp. 35-62). Elsevier:
Ottewell, P.D., & Quayle, L.A. (2020). Tumor Dormancy in The Bone. In Encyclopedia of Bone Biology. (pp. 166-179). Elsevier:
Theses / Dissertations
Quayle, L. (2018). Identification and Characterisation of Mitotically Quiescent Sub-Clones in Breast Cancer. (Doctoral thesis). Supervised by Ottewell, P., & Holen, I.
Software / Code
Quayle, L. (2022). . Sheffield University.
Other activities
Editorial Board Member - Clinical & Experimental Metastasis
Reviewer for Acta Pharmaceutica Sinica B, Cancer Chemotherapy and Pharmacology, Clinical & Experimental Metastasis, Discover Oncology, Journal of Cellular Biochemistry, Journal of Tissue Engineering and Regenerative Medicine, Scientific Reports
Instructor - Data, Software and Library Carpentry (The Carpentries: )
Postgraduate supervision
Ronak Naeemaee - Fully funded GTA PhD Studentship - Unlocking Precision Medicine: Advanced Survival Analysis Tools for Cancer Biomarker Validation
Media
Personal website: /
YouTube:
GitHub:
Linkedin:
Ï㽶ÊÓƵGate: