Professor Emerita Nicola Woodroofe BSc, PhD, SFHEA
Professor Emerita
- School of Biosciences and Chemistry
- Biomolecular Sciences Ï㽶ÊÓƵ Centre
- Industry and Innovation Ï㽶ÊÓƵ Institute
Summary
I was appointed as a senior lecturer at Ï㽶ÊÓƵ in 1994, after completing my BSc and PhD in Biochemistry at the University of London and 15 years as a postdoctoral researcher. I was promoted to Professor in 2005 based on my international profile in the field of neuroimmunology and specifically multiple sclerosis. I retired in 2020 and I am now an emeritus professor.
About
After appointment as a senior lecturer , I taught cell biology, immunology, pathological sciences and neuroscience at undergraduate and masters levels. I have supervised over 25 research students to complete their doctoral degrees. I have collaborated with consultant neurologists at Sheffield Teaching Hospitals NHS Foundation Trust for many years specifically in research on multiple sclerosis and gluten ataxia. I have published around 100 papers and abstracts and presented my research work at international conferences.
I continue to act as a referee for a number of journals and grant awarding bodies.
Specialist areas of interest
Neuroimmunology, autoimmunity, metalloproteinases, cytokines and chemokines
Ï㽶ÊÓƵ
Investigations of the pathogens of multiple sclerosis
Publications
Journal articles
Rawlinson, K.E., Duckett, C., Shaw, H., Woodroofe, M.N., & Lacey, M. (2021). . International Journal of Science Education, Part B: Communication and Public Engagement.
Pousinis, P., Ramos, I.R., Woodroofe, M.N., & Cole, L.M. (2020). . Metabolites, 10 (9), e366.
Aldewachi, H., Chalati, T., Woodroofe, N., Bricklebank, N., Sharack, B., & Gardiner, P. (2018). . Nanoscale, 10 (1), 18-33.
Salman, M., Kitchen, P., Woodroofe, N., Bill, R.M., Conner, A.C., Heath, P.R., & Conner, M.T. (2017). . Frontiers in cellular neuroscience, 11, 386.
Ramos, I., Lyng, F.M., Rehman, I.U., Sharrack, B., & Woodroofe, N. (2017). . Applied Spectroscopy Reviews, 52.
Salman, M., Kitchen, P., Woodroofe, N., Brown, J.E., Bill, R.M., Conner, A.C., & Conner, M.T. (2017). . European Journal of Neuroscience, 46 (9), 2542-2547.
Salman, M., Sheilabi, M.A., Bhattacharyya, D., Kitchen, P., Conner, A.C., Bill, R.M., ... Princivalle, A. (2017). . The European Journal of Neuroscience, 46 (5), 2121-2132.
Aldewachi, H., Woodroofe, N., Turega, S., & Gardiner, P. (2017). . Talanta, 169, 13-19.
Crank, H., Carter, A., Humphreys, L., Snowdon, N., Daley, A., Woodroofe, N., ... Saxton, J.M. (2017). . Archives of Physical Medicine and Rehabilitation, 98 (12), 2520-2525.
Waller, R., Woodroofe, N., Wharton, S.B., Ince, P.G., Francese, S., Heath, P.R., ... Simpson, J.E. (2016). . Journal of Neuroimmunology, 299, 139-146.
Shanmugarajah, P.D., Hoggard, N., Currie, S., Aeschlimann, D.P., Aeschlimann, P.C., Gleeson, D.C., ... Hadjivassiliou, M. (2016). Cerebellum & Ataxias.
Carter, A., Humphreys, L., Snowdon, N., Sharrack, B., Daley, A., Petty, J., ... Saxton, J. (2015). . Trials, 16 (1).
Amor, S., & Woodroofe, N. (2014). . Immunology, 141 (3), 287-291.
Carter, A., Daley, A., Humphreys, L., Snowdon, N., Woodroofe, N., Petty, J., ... Saxton, J. (2014). . Multiple Sclerosis, 20 (8), 1112-1122.
Saxton, J., Scott, E.J., Daley, A.J., Woodroofe, N., Mutrie, N., Crank, H., ... Coleman, R.E. (2014). . Breast Cancer Ï㽶ÊÓƵ, 16 (2), R39.
Battle, R., Turner, D., Woodroofe, N., & Clark, B. (2014). . Immunology Letters, 161 (1), 57-58.
Bradford, C.M., Ramos, I., Cross, A.K., Haddock, G., McQuaid, S., Nicholas, A.P., & Woodroofe, M.N. (2014). . Journal of Neuroimmunology, 273 (1-2), 85-95.
Saxton, J.M., Scott, E., Daley, A.J., Woodroofe, M.N., Mutrie, N., Crank, H., ... Coleman, R.E. (2014). . Breast Cancer Ï㽶ÊÓƵ, 16 (2), R39.
Carter, A.M., Daley, A.J., Kesterton, S.W., Woodroofe, N., Saxton, J.M., & Sharrack, B. (2013). . Contemporary Clinical Trials, 35 (2), 40-47.
Kelly, D.M., Sellers, D.J., Woodroofe, M.N., Jones, T.H., & Channer, K.S. (2013). . Endocrine Ï㽶ÊÓƵ, 38 (3), 125-138.
Hart, P.J., Francese, S., Woodroofe, M.N., & Clench, M.R. (2013). . International Journal for Ion Mobility Spectrometry, 16 (2), 71-83.
Battle, R., Woodroofe, N., Clench, M., & Clark, B. (2013). The relationship of HLA-class I derived leader peptide mismatch and renal function within the first 12 months post-renal transplant. Tissue antigens, 82 (4), 291-292.
Hadjivassiliou, M., Aeschlimann, P., Sanders, D.S., Mäki, M., Kaukinen, K., Grünewald, R.A., ... Aeschlimann, D.P. (2013). Transglutaminase 6 antibodies in the diagnosis of gluten ataxia. Neurology, 80 (19), 1740-1745.
Saxton, J., Carter, A., Daley, A.J., Snowdon, N., Woodroofe, N., Petty, J., ... Sharrack, B. (2013). . Contemporary Clinical Trials, 34 (2), 205-211.
Scott, E., Daley, A.J., Doll, H., Woodroofe, N., Mutrie, N., Crank, H., ... Saxton, J. (2013). . Cancer Causes and Control, 24 (1), 181-191.
Stout, M., Tew, G.A., Doll, H., Zwierska, I., Woodroofe, N., Channer, K.S., & Saxton, J.M. (2012). . American Heart Journal, 164 (6), 893-901.
Battle, R., Poole, K., Haywood-Small, S., Clark, B., & Woodroofe, N. (2012). . International Journal of Cancer, 132 (1), 246-247.
Hurst, L.A., Bunning, R.A.D., Sharrack, B., & Woodroofe, M.N. (2012). . Neuroscience Letters, 521 (1), 52-56.
Fouillet, A., Mawson, J., Suliman, O., Sharrack, B., Romero, I.A., & Woodroofe, N.W. (2012). . Brain Ï㽶ÊÓƵ, 1437, 115-126.
Frentzou, G., Bradford, C., Harkness, K.A., Haddock, G., Woodroofe, N.W., & Cross, A. (2012). . Journal of Molecular Neuroscience, 46 (2), 343-351.
Waller, R., Woodroofe, M.N., Francese, S., Heath, P.R., Wharton, S.B., Ince, P.G., ... Simpson, J.E. (2012). . Journal of Neuroscience Methods, 208 (2), 108-113.
Hart, P.J., Francese, S., Claude, E., Woodroofe, M.N., & Clench, M.R. (2011). . Analytical and Bioanalytical Chemistry, 401 (1), 115-125.
Hadjivassiliou, M., Aeschlimann, D., Gruenewald, R.A., Sanders, D.S., Sharrack, B., & Woodroofe, N.W. (2011). . Acta Neurologica Scandinavica, 123 (3), 175-180.
Bradford, C.M., Cross, A., Haddock, G., Woodroofe, N.W., & Sharrack, B. (2011). . Future Neurology, 6 (4), 521-530.
Dhungana, S., Waters, P., Ismail, A., Woodroofe, N., Vincent, A., & Sharrack, B. (2010). . Journal of Neurology, 257 (7), 1211-1212.
Dhungana, S., Sharrack, B., & Woodroofe, N. (2010). . Acta neurologica Scandinavica, 121 (2), 71-82.
Hadjivassiliou, M., Sanders, D.S., Grunewald, R.A., Woodroofe, N., Boscolo, S., & Aeschlimann, D. (2010). . The Lancet Neurology, 9 (3), 318-330.
Dhungana, S., Waters, P., Ismail, A., Woodroofe, N., Vincent, A., & Sharrack, B. (2010). Erratum to: Absence of aquaporin-4 antibodies in patients with idiopathic intracranial hypertension. Journal of Neurology, 257 (7), 1229-1230.
Dhungana, S., Sharrack, B., & Woodroofe, N. (2009). . Headache: the journal of head and face pain, 49 (2), 282-285.
Taylor, D., Dalton, C., Hall, A., Woodroofe, M.N., & Gardiner, P. (2009). Recent developments in selenium research. British journal of biomedical science, 66 (2), 107-116.
Denney, H., Clench, M., & Woodroofe, M.N. (2009). . Biochemical and biophysical research communications, 382 (2), 341-347.
Hurst, L.A., Bunning, R.A.D., Couraud, P.-.O., Romero, I.A., Weksler, B.B., Sharrack, B., & Woodroofe, M.N. (2009). . Journal of neuroimmunology, 210 (1-2), 108-112.
Reid, M.J., Cross, A.K., Haddock, G., Allan, S.M., Stock, C.J., Woodroofe, M.N., ... Bunning, R.A.D. (2009). . Neuroscience letters, 452 (3), 252-257.
Bradford, C.M., Cross, A.K., Haddock, G., & Woodroofe, M.N. (2009). . British journal of neuroscience nursing, 5 (1), 1-13.
Hadjivassiliou, M., Boscolo, S., Tongiorgi, E., Grünewald, R.A., Sharrack, B., Sanders, D.S., ... Davies-Jones, G.A.B. (2008). . Movement disorders, 23 (10), 1370-1377.
Hadjivassiliou, M., Sanders, D.S., Woodroofe, N., Williamson, C., & Grünewald, R.A. (2008). . The Cerebellum, 7 (3), 494-498.
Hadjivassiliou, M., Aeschlimann, P., Strigun, A., Sanders, D.S., Woodroofe, N., & Aeschlimann, D. (2008). . Annals of neurology, 64 (3), 332-343.
Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J.T., Bunning, R.A., ... Woodroofe, M.N. (2007). . Biochemical Society Transactions, 35 (4), 692.
Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A., ... Woodroofe, N. (2006). . Brain research, 1088 (1), 19-30.
Hadjivassiliou, M., Mäki, M., Sanders, D.S., Williamson, C.A., Grünewald, R.A., Woodroofe, N.M., & Korponay-Szabó, I.R. (2006). Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology, 66 (3), 373-377.
Cross, A.K., Haddock, G., Surr, J., Plumb, J., Buttle, D.J., & Woodroofe, N. (2005). . Journal of autoimmunity, 26 (1), 16-23.
Haddock, G., Cross, A.K., Plumb, J., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2005). . Multiple Sclerosis, 12 (4), 386-396.
Plumb, J., McQuaid, S., Cross, A.K., Surr, J., Haddock, G., Bunning, R.A.D., & Woodroofe, M.N. (2005). . Multiple Sclerosis, 12 (4), 375-385.
Plumb, J., Cross, A.K., Surr, J., Haddock, G., Smith, T., Bunning, R.A.D., & Woodroofe, M.N. (2005). ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. Journal of neuroimmunology, 164 (1-2), 1-9.
Hadjivassiliou, M., Williamson, C.A., & Woodroofe, N. (2004). The immunology of gluten sensitivity: beyond the gut. Trends in immunology, 25 (11), 578-582.
Harkness, K.A., Sussman, J.D., Davies-Jones, G.A.B., Greenwood, J., & Woodroofe, M.N. (2003). Cytokine regulation of MCP-1 expression in brain and retinal microvascular endothelial cells. Journal of neuroimmunology, 142 (1-2), 1-9.
Kemp, H.E., Metcalfe, R.A., Smith, K.A., Woodroofe, M.N., Watson, P.F., & Weetman, A.P. (2003). . Clinical endocrinology, 59 (2), 207-213.
Mahad, D.J., Lawry, J., Howell, S.J.L., & Woodroofe, M.N. (2003). Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse. Multiple sclerosis (Houndmills, Basingstoke, England), 9 (2), 189-198.
Hadjivassiliou, M., Grünewald, R., Sharrack, B., Sanders, D., Lobo, A., Williamson, C., ... Davies-Jones, A. (2003). Gluten ataxia in perspective: epidemiology, genetic susceptibility and clinical characteristics. Brain : a journal of neurology, 126 (Pt 3), 685-691.
Mahad, D.J., Howell, S.J.L., & Woodroofe, N. (2002). . Journal of neurology neurosurgery and psychiatry, 73 (3), 320-323.
Mahad, D.J., Howell, S.J.L., & Woodroofe, M.N. (2002). Expression of chemokines in the CSF and correlation with clinical disease activity in patients with multiple sclerosis. Journal of neurology, neurosurgery, and psychiatry, 72 (4), 498-502.
Hadjivassiliou, M., Boscolo, S., Davies-Jones, G.A.B., Grünewald, R.A., Not, T., Sanders, D.S., ... Woodroofe, N.M. (2002). The humoral response in the pathogenesis of gluten ataxia. Neurology, 58 (8), 1221-1226.
Kieseier, B.C., Tani, M., Mahad, D., Oka, N., Ho, T., Woodroofe, N., ... Hartung, H.-.P. (2001). . Brain, 125 (4), 823-834.
Cross, A.K., & Woodroofe, M.N. (2001). Immunoregulation of microglial functional properties. Microscopy research and technique, 54 (1), 10-17.
Goddard, D.R., Bunning, R.A.D., & Woodroofe, M.N. (2001). . Glia, 34 (4), 267.
John, G.R., Simpson, J.E., Woodroofe, N., Lee, S.C., & Brosnan, C.F. (2001). . Journal of Neuroscience, 21 (12), 4134-4142.
De Groot, C.J., & Woodroofe, M.N. (2001). The role of chemokines and chemokine receptors in CNS inflammation. Progress in brain research, 132, 533-544.
Simpson, J., Rezaie, P., Newcombe, J., Cuzner, M.L., Male, D., & Woodroofe, M.N. (2000). Expression of the beta-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue. Journal of neuroimmunology, 108 (1-2), 192-200.
Simpson, J.E., Newcombe, J., Cuzner, M.L., & Woodroofe, M.N. (2000). Expression of the interferon-gamma-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions. Neuropathology and applied neurobiology, 26 (2), 133-142.
Harkness, K.A., Adamson, P., Sussman, J.D., Davies-Jones, G.A., Greenwood, J., & Woodroofe, M.N. (2000). Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium. Brain : a journal of neurology, 123 ( Pt 4), 698-709.
Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. Glia, 28 (3), 183-189. http://doi.org/10.1002/(sici)1098-1136(199912)28:3<183::aid-glia2>3.0.co;2-3
Cross, A.K., & Woodroofe, M.N. (1999). Chemokine modulation of matrix metalloproteinase and TIMP production in adult rat brain microglia and a human microglial cell line in vitro. Glia, 28 (3), 183-189. http://doi.org/10.1002/(sici)1098-1136(199912)28:3<183::aid-glia2>3.0.co;2-3
Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. Journal of neuroscience research, 55 (1), 17-23. http://doi.org/10.1002/(sici)1097-4547(19990101)55:1<17::aid-jnr3>3.0.co;2-j
Woodroofe, N., Cross, A.K., Harkness, K., & Simpson, J.E. (1999). The role of chemokines in the pathogenesis of multiple sclerosis. Advances in experimental medicine and biology, 468, 135-150.
Cross, A.K., & Woodroofe, M.N. (1999). Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro. Journal of Neuroscience Ï㽶ÊÓƵ, 55 (1), 17-23. http://doi.org/10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3>3.0.CO;2-J
Simpson, J.E., Newcombe, J., Cuzner, M.L., & Woodroofe, M.N. (1998). Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions. Journal of neuroimmunology, 84 (2), 238-249.
Loughlin, A.J., & Woodroofe, M.N. (1996). Inhibitory effect of interferon-gamma on LPS-induced interleukin 1 beta production by isolated adult rat brain microglia. Neurochemistry international, 29 (1), 77-82.
Windhagen, A., Newcombe, J., Dangond, F., Strand, C., Woodroofe, M.N., Cuzner, M.L., & Hafler, D.A. (1995). Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. The Journal of experimental medicine, 182 (6), 1985-1996.
Woodroofe, M.N. (1995). Cytokine production in the central nervous system. Neurology, 45 (6 Suppl 6), S6-10.
Brosnan, C.F., Cannella, B., Battistini, L., & Raine, C.S. (1995). Cytokine localization in multiple sclerosis lesions: correlation with adhesion molecule expression and reactive nitrogen species. Neurology, 45 (6 Suppl 6), S16-S21.
Woodroofe, M.N., Dantzer, R., Gutierrez, E.G., Banks, W.A., Kastin, A.J., Ortiz, L., ... Brown, A. (1995). Cytokine production in the central nervous system. Neurology, 45 (6), S6-S10.
Woodroofe, M.N., Cuzner, M.L., & Ironside, J.W. (1994). In situ hybridization in neuropathology. Neuropathology and applied neurobiology, 20 (6), 562-572.
Zoukos, Y., Kidd, D., Woodroofe, M.N., Kendall, B.E., Thompson, A.J., & Cuzner, M.L. (1994). Increased expression of high affinity IL-2 receptors and beta-adrenoceptors on peripheral blood mononuclear cells is associated with clinical and MRI activity in multiple sclerosis. Brain : a journal of neurology, 117 ( Pt 2), 307-315.
Loughlin, A.J., Honegger, P., Woodroofe, M.N., Comte, V., Matthieu, J.M., & Cuzner, M.L. (1994). Myelin basic protein content of aggregating rat brain cell cultures treated with cytokines and/or demyelinating antibody: effects of macrophage enrichment. Journal of neuroscience research, 37 (5), 647-653.
Cuzner, M.L., Loughlin, A.J., Mosley, K., & Woodroofe, M.N. (1994). The role of microglia macrophages in the processes of inflammatory demyelination and remyelination. Neuropathology and applied neurobiology, 20 (2), 200-201.
Woodroofe, M.N., & Cuzner, M.L. (1993). Cytokine mRNA expression in inflammatory multiple sclerosis lesions: detection by non-radioactive in situ hybridization. Cytokine, 5 (6), 583-588.
Loughlin, A.J., Woodroofe, M.N., & Cuzner, M.L. (1993). Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids. Immunology, 79 (1), 125-130.
Loughlin, A.J., Woodroofe, M.N., & Cuzner, M.L. (1992). Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide: effects on interferon-gamma induced activation. Immunology, 75 (1), 170-175.
Woodroofe, M.N., Sarna, G.S., Wadhwa, M., Hayes, G.M., Loughlin, A.J., Tinker, A., & Cuzner, M.L. (1991). Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. Journal of neuroimmunology, 33 (3), 227-236.
Newcombe, J., Hawkins, C.P., Henderson, C.L., Patel, H.A., Woodroofe, M.N., Hayes, G.M., ... McDonald, W.I. (1991). Histopathology of multiple sclerosis lesions detected by magnetic resonance imaging in unfixed postmortem central nervous system tissue. Brain : a journal of neurology, 114 ( Pt 2), 1013-1023.
Woodroofe, M.N., Hayes, G.M., & Cuzner, M.L. (1989). Fc receptor density, MHC antigen expression and superoxide production are increased in interferon-gamma-treated microglia isolated from adult rat brain. Immunology, 68 (3), 421-426.
Cuzner, M.L., Hayes, G.M., Newcombe, J., & Woodroofe, M.N. (1988). The nature of inflammatory components during demyelination in multiple sclerosis. Journal of neuroimmunology, 20 (2-3), 203-209.
Hayes, G.M., Woodroofe, M.N., & Cuzner, M.L. (1988). Characterisation of microglia isolated from adult human and rat brain. Journal of neuroimmunology, 19 (3), 177-189.
Hayes, G.M., Woodroofe, M.N., & Cuzner, M.L. (1988). Microglia express MHC class II in normal and demyelinating human white matter. Annals of the New York Academy of Sciences, 540, 501-503.
Hayes, G.M., Woodroofe, M.N., & Cuzner, M.L. (1987). Microglia are the major cell type expressing MHC class II in human white matter. Journal of the neurological sciences, 80 (1), 25-37.
Newcombe, J., Woodroofe, M.N., & Cuzner, M.L. (1986). Distribution of glial fibrillary acidic protein in gliosed human white matter. Journal of neurochemistry, 47 (6), 1713-1719.
Woodroofe, M.N., Bellamy, A.S., Feldmann, M., Davison, A.N., & Cuzner, M.L. (1986). Immunocytochemical characterisation of the immune reaction in the central nervous system in multiple sclerosis. Possible role for microglia in lesion growth. Journal of the neurological sciences, 74 (2-3), 135-152.
Woodroofe, M.N., Tunnacliffe, A., Pym, B., Goodfellow, P.N., & Walsh, F.S. (1984). Human muscle cell surface antigen 16.3A5 is encoded by a gene on chromosome 11. Somatic cell and molecular genetics, 10 (5), 535-540.
Lim, S.S., Woodroofe, M.N., & Lemanski, L.F. (1983). An analysis of contractile proteins in developing chick heart by SDS polyacrylamide gel electrophoresis and electron microscopy. Journal of embryology and experimental morphology, 77, 1-14.
Woodroofe, M.N., & Lemanski, L.F. (1981). Two actin variants in developing axolotl heart. Developmental biology, 82 (1), 172-179.
Woodroofe, M.N., & Butterworth, P.J. (1979). Evidence for the importance of arginine residues in pig kidney alkaline phosphatase. The Biochemical journal, 181 (1), 137-142.
Woodroofe, M.N., & Butterworth, P.J. (1978). Chemical-modification studies on pig kidney alkaline phosphatase [proceedings]. Biochemical Society transactions, 6 (3), 562-564.
Conference papers
Salman, M., Kitchen, P., Heath, P., Belli, A., Woodroofe, M.N., Bill, R., ... Conner, M. (2017). Location matters: the role of calmodulin-mediated AQP4 translocation in human astrocyte response to hypoxia and mild hypothermia. JOURNAL OF NEUROCHEMISTRY, 142, 85.
Salman, M., Kitchen, P., Heath, P., Bill, R., Conner, A., Woodroofe, M.N., & Conner, M. (2017). Location matters: the role of calmodulin mediated AQP4 translocation in the human astrocyte response to hypoxia and mild hypothermia. GLIA, 65, E329.
Abuneeza, E., Cross, A., Haddock, G., Bunning, R., & Woodroofe, N. (2014). . Journal of Neuroimmunology, 275 (1-2), 131-132.
Battle, R., Woodroofe, M.N., Clench, M., Bradshaw, R., Harrison, P., & Clark, B. (2013). A bioinformatics and proteomic approach for the identification of peptides derived from HLA class I molecules and presented by HLA-A*02. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 40 (5), 414.
Woodroofe, M.N., Sinagra, M., Bunning, R., Bolton, C., & Azzouz, M. (2013). EFFECT OF SILENCING ADAM17 EXPRESSION BY AN ADENOVIRAL VECTOR-MEDIATED RNA INTERFERENCE APPROACH IN CHRONIC RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS. GLIA, 61, S43.
Battle, R., Woodroofe, M.N., Clench, M., & Clark, B. (2013). HLA-Class I leader peptide sequence mismatches between renal transplant donors and recipients are associated with a reduction in allograft function within the first 12 months post transplant. INTERNATIONAL JOURNAL OF IMMUNOGENETICS, 40 (5), 403.
Bokhamada, H.K., Woodroofe, M.N., Jones, T.H., Small, S.H., Kay, W., & Dalton, C.F. (2013). Investigation of the effect of testosterone treatment on the expression of chemokine receptors in monocyte/macrophage THP-1 cell line. Atherosclerosis, 231 (2), e6.
Waller, R., Heath, P.R., Woodroofe, M.N., Francese, S., Wharton, S.B., Ince, P.G., ... Simpson, J.E. (2012). Microarray analysis of the astrocyte transcriptome in normal appearing white matter in multiple sclerosis. JOURNAL OF NEUROIMMUNOLOGY, 253 (1-2), 54.
Bradford, C.M. (2012). .
Bradford, C.M. (2012). .
Kelly, D.M., Sellers, D.J., Woodroofe, M.N., Jones, T.H., & Channer, K.S. (2010). Effect of Testosterone on Inflammatory Markers in Development of Early Atherogenesis in the Testicular Feminised Mouse (Tfm) Model. ENDOCRINE REVIEWS, 31 (3).
Frentzou, G.A., Kamara, C., Harkness, K.A., Haddock, G., Doyle, C., Taylor, M., ... Randall, M. (2010). POS07 Reduced ADAMTS-13 activity levels in partial anterior circulation transient ischaemic attack patients compared to nonstroke controls. Journal of Neurology, Neurosurgery & Psychiatry, 81 (11), e69.
Woodroofe, N.W., Sellers, D., Channer, K.S., & Kelly, D.M. (2008). . Immunology, 125 (1), 116-117.
Dhungana, S., Woodroofe, M.N., Sharrack, B., Howell, S.J., & Price, S.E. (2007). Cerebrospinal fluid and serum cytokine profile in patients with idiopathic intracranial hypertension. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 78 (9), 1025.
Hurst, L.A., Bunning, R.A.D., Sharrack, B., & Woodroofe, M.N. (2007). A functional role for ADAM-17 in the pathogenesis of multiple sclerosis. IMMUNOLOGY, 120, 32.
Fouillet, A., Romero, I.A., & Woodroofe, M.N. (2007). Astrocytes regulate CCL2 level in CCR2-independent way. PROCEEDINGS OF THE VIII EUROPEAN MEETING ON GLIAL CELLS IN HEALTH AND DISEASE, 79-+.
Haddock, G., Cross, A.K., Allan, S., Bunning, R.A.D., Buttle, D.J., & Woodroofe, M.N. (2007). Changes in brain expression of chondroitin sulphate proteoglycans following transient middle cerebral artery occlusion in the rat. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 88 (6), A92.
Suliman, O., Sharrack, B., Howell, S., Price, S., & Woodroofe, M.N. (2007). Longitudinal study of expression of CCL2 and CXCL10 in the serum of patients with multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 78 (9), 1036.
Haddock, G., Cross, A.K., Allan, S., Sharrack, B., Callaghan, J., Bunning, R.A.D., ... Woodroofe, M.N. (2007). Brevican and phosphacan expression and localization following transient middle cerebral artery occlusion in the rat. Biochemical Society Transactions, 35 (4), 692-694.
Cross, A.K., Haddock, G., Stock, C.J., Allan, S., Surr, J., Bunning, R.A.D., ... Woodroofe, M.N. (2006). ADAMTS-1 and-4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by cytokines in astrocytes and endothelial cell cultures. JOURNAL OF NEUROIMMUNOLOGY, 178, 249.
Reid, M.J., Allan, S., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2006). ADAMTS-9 is upregulated at the mRNA level following middle cerebral artery occlusion in rats. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 87 (1), A28.
Suliman, O., Howell, S.J., Lawry, J., Sharrack, B., & Woodroofe, M.N. (2006). Longitudinal study of chemokine receptor expression on CD4+ and CD8+ T cells and CD14+ monocytes in patients with relapsing and remitting multiple sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 77 (12), 1399.
Laird, S.M., Calverley, H., Audley, A.M., Scott, M., Li, T.C., & Woodroofe, M.N. (2005). Expression of CXCR1 and CXCR3 in human endometrium; Effects of their ligands on endometrial cell function. PLACENTA, 26 (8-9), A28.
Reid, M.J., Cross, A.K., Woodroofe, M.N., Buttle, D.J., & Bunning, R.A.D. (2005). Pro-inflammatory cytokines modulate a disintegrin and metalloproteinase domain with thrombospondin motif S-9 mRNA expression in human glial cell lines. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 86 (6), A81-A82.
Denney, H., Clench, M., & Woodroofe, M.N. (2005). Investigations into the significance of the truncation of chemokines CCL2 and CXCL10 by MMP2, MMP9, and CD26, in multiple sclerosis. IMMUNOLOGY, 116, 42.
Hadjivassiliou, M., Williamson, C.A., Grünewald, R.A., & Woodroofe, M.N. (2004). Glutamic acid decarboxylase as a target antigen in gluten sensitivity:: the link to neurological manifestations? JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 97.
Williamson, C.A., Grünewald, R.A., Woodroofe, M.N., & Hadjivassiliou, M. (2004). An investigation into the specificity of circulating anti-cerebellar antibodies involved in the humoral immune response associated with gluten ataxia. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 97.
Haddock, G., Cross, A.K., Bunning, R.A.D., Plumb, J., Surr, J., Buttle, D.J., ... Woodroofe, M.N. (2004). Expression of ADAMTS-1, -4 -5 and TIMP-3 in different stages of experimental autoimmune encephalomyelitis. JOURNAL OF NEUROIMMUNOLOGY, 154 (1-2), 58.
Plumb, J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Cytokine regulation of TACE and TIMP 3 production by astrocyte and endothelial cells. GLIA, 42-43.
Haddock, G., Cross, A.K., Surr, J., Buttle, D.J., Bunning, R.A.D., & Woodroofe, M.N. (2003). Expression of ADAMTS-1,-4-5 and TIMP-3 in central nervous system cell lines: Possible role in CNS physiology and pathology. GLIA, 33.
Mahad, D., Oates, K., Williams, C., Grünewald, R., Howell, S.J.L., Woodroofe, M.N., & Hajivassiliou, M. (2002). Gluten ataxia is immune mediated. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 72 (1), 140.
Williamson, C.A., Grunewald, R.A., Woodroofe, M.N., & Hadjivassiliou, M. (2002). An investigation of anti-cerebellar antibodies in gluten ataxia. GLIA, S77.
Gill, K.A., & Woodroofe, M.N. (2002). Effect of extracellular matrix components on the presentation of chemokines and migration of microglia and astrocyte cell lines. GLIA, S42-S43.
Mahad, D.J., Woodroofe, M.N., & Howell, S.J. (2001). Cerebrospinal fluid concentrations of chemokines and Th1 lymphocytes in patients with multiples sclerosis. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 70 (2), 274.
Hadjivassiliou, M., Grunewald, R.A., Davies-Jones, G.A.B., Simpson, J.E., Williamson, C.A., Woodroofe, M.N., ... Not, T. (2001). Humoral response in the pathogenesis of gluten ataxia. ANNALS OF NEUROLOGY, 50 (3), S37.
Simpson, J.E., & Woodroofe, M.N. (2001). Inflammation in the central nervous system in multiple sclerosis: The role of chemokines and their receptors. InflammoPharmacology, 9 (1-2), 23-33.
Mahad, D.J., Woodroofe, M.N., & Howell, S.J. (2000). Chemokine expression in cerebrospinal fluid of multiple sclerosis. ANNALS OF NEUROLOGY, 48 (3), 452.
Woodroofe, M.N. (1996). Cytokine expression by microglia in vitro and in the central nervous system in multiple sclerosis. JOURNAL OF PHYSIOLOGY-LONDON, 493P, S45-S46.
CUZNER, M.L., WOODROOFE, M.N., & LOUGHLIN, A.J. (1993). REGULATION OF THE FUNCTIONAL-PROPERTIES OF MICROGLIA BY CYTOKINES. JOURNAL OF NEUROCHEMISTRY, 61, S238.
Hayes, G.M., Woodroofe, M.N., & Cuzner, M.L. (1987). The identification of myelin basic protein by class II+ migroglia in white matter from multiple sclerosis brain. Journal of Neuroimmunology, 16 (1), 75.
WALSH, F.S., MOORE, S.E., WOODROOFE, M.N., HURKO, O., NAYAK, R., & BROWN, S.M. (1983). DEVELOPMENTALLY REGULATED ANTIGENS OF HUMAN-MUSCLE. HYBRIDOMA, 2 (2), 243.
WOODROOFE, M.N., MOORE, S., DHUT, S., & WALSH, F.S. (1982). CHARACTERIZATION OF HUMAN-MUSCLE FIBER TYPE SPECIFIC ANTIGENS USING MONOCLONAL-ANTIBODIES. BIOLOGY OF THE CELL, 45, 272.
LIMSPIKER, S., WOODROOFE, M.N., & LEMANSKI, L.F. (1981). ANALYSIS OF MUSCLE PROTEINS IN DEVELOPING CHICK HEART. JOURNAL OF CELL BIOLOGY, 91 (2), A349.
WOODROOFE, M.N., & LEMANSKI, L.F. (1980). ACTIN IN CARDIAC MUTANT AND NORMAL AXOLOTL HEARTS. JOURNAL OF CELL BIOLOGY, 87 (2), A266.
WOODROOFE, M.N., LIMSPIKER, S., & LEMANSKI, L.F. (1980). CHICK HEART DEVELOPMENT ANALYZED BY 2 DIMENSIONAL GEL-ELECTROPHORESIS AND ELECTRON-MICROSCOPY. JOURNAL OF CELL BIOLOGY, 87 (2), A266.
Book chapters
Woodroofe, N., & Amor, S. (2014). . In Woodroofe, N., & Amor, S. (Eds.) Neuroinflammation and CNS Disorders. (pp. 1-8). Wiley:
Woodroofe, N., & Amor, S. (2014). . In Woodroofe, N., & Amor, S. (Eds.) Neuroinflammation and CNS Disorders. (pp. 1-8). Wiley:
Bradford, C., Nicholas, A.P., Cross, A.K., & Woodroofe, N. (2013). . In Nicholas, A.P., & Bhattacharya, S.K. (Eds.) Protein deimination in human health and disease. (pp. 165-185). Springer:
Woodroofe, M.N., & Bunning, R.A.D. (n.d.). Proteases and Peptidases in EAE. In Experimental Models of Multiple Sclerosis. (pp. 391-413). Springer US:
Books
Woodroofe, N., & Amor, S. (Eds.). (2014). Neuroinflammation and CNS Disorders. Wiley.
Theses / Dissertations
Salman, M. (2018). . (Doctoral thesis). Supervised by Woodroofe, N., & Conner, M.
Sholademi, B.A. (2017). . (Doctoral thesis). Supervised by Woodroofe, N.
Mounsey, K.L. (2016). . (Doctoral thesis). Supervised by Woodroofe, N.
Abuneeza, E. (2015). . (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., Cross, A., & Haddock, G.
Battle, R. (2014). . (Doctoral thesis). Supervised by Woodroofe, N., & Clark, B.
Bokhamada, H. (2014). . (Doctoral thesis). Supervised by Dalton, C., Woodroofe, N., & Jones, H.
Chen, Y.-.F. (2014). . (Doctoral thesis). Supervised by Rust, C., & Woodroofe, N.
Barraclough, J. (2012). . (Doctoral thesis). Supervised by Woodroofe, N.
Hart, P.J. (2012). . (Doctoral thesis). Supervised by Clench, M., Woodroofe, N., & Francese, S.
Kelly, D.M. (2010). . (Doctoral thesis). Supervised by Woodroofe, N., & Sellers, D.
Williams, M. (2010). . (Doctoral thesis). Supervised by Lubenko, A., Norfolk, D., Soltani, H., & Woodroofe, N.
Hurst, L.A. (2009). . (Doctoral thesis). Supervised by Woodroofe, N., & Bunning, R.
Moin, M. (2009). . (Doctoral thesis). Supervised by Khan, A., & Woodroofe, N.
Vahabi, B. (2009). . (Doctoral thesis). Supervised by Sellers, D., Mckay, N., Lawson, K., & Woodroofe, N.
Denney, H.A. (2008). . (Doctoral thesis). Supervised by Woodroofe, N., Bunning, R., & Clench, M.
Reid, M.J. (2007). . (Doctoral thesis). Supervised by Bunning, R., Battle, D., & Woodroofe, N.
Welbourn, J.T. (2007). . (Doctoral thesis). Supervised by Blair, M., & Woodroofe, N.
Plumb, J. (2005). . (Doctoral thesis). Supervised by Woodroofe, N., & Bunning, R.
Williamson, C.A. (2003). . (Doctoral thesis). Supervised by Woodroofe, N., & Hadjivasiliou, M.
Other activities
- Committee member European School of Neuroimmunology
- Committee member International Society of Neuroimmunology
Postgraduate supervision
I have supervised PhD students both at Ï㽶ÊÓƵ and The University of Sheffield, including clinicians, with most of these focussed on multiple sclerosis research. I have also supervised professional doctorate students working in NHS pathology laboratories as well as at the NHS Blood Transfusion Service laboratories.
Media
Nicola was the Head of the University's Biomolecular Sciences Ï㽶ÊÓƵ Centre until the end of December 2018 and has worked within biomedical research for over 30 years, with particular focus on multiple sclerosis (MS). Nicola's main interest is in the study of post-mortem brain tissue using pathological and immunological techniques to get an understanding of the immune mechanisms within the brain of an MS patient. Nicola chairs the Women Professors' Group which seeks to support and inspire female academics to advance their careers to professorial level and she is also a champion of women in science.