Doctor Nikki Jordan-Mahy BSc, PhD
Associate Head
Summary
Dr. Nikki Jordan-Mahy is an Associate Head, Ï㽶ÊÓƵ Delivery Manager and Principal Lecturer at Ï㽶ÊÓƵ. She is a graduate of Royal Holloway and Bedford New College at the University of London where she received a BSc Hons degree in Physiology and Zoology. On completion of her degree she undertook her PhD at Cambridge University at the MRC Dunn Nutrition Unit. She has taught in many areas including physiology, anatomy, embryology, pathology, forensic pathology and nutrition. She is a member of the Cancer Ï㽶ÊÓƵ Group and the Tissue engineering Ï㽶ÊÓƵ Group in the Biomolecular Ï㽶ÊÓƵ Centre (BMRC). Nikki supervises a number of PhD students within these two research areas.
About
Nikki is an experiential teacher and has been nominated for the College and University Inspirational Teaching Award in 2013, 2014, 2015 and 2016 and won the University Award in 2014, 2015 and 2016. She was awarded the VC Inspirational Teaching Award in 2016.
She has worked in the Department of Biosciences and Chemistry for 25 years, and during this time, she has developed modules and course programs of study for undergraduates and postgraduates. She has planned key roles in the seven BSc/MSci course validation processes, in several successful accreditation from the Royal Society of Biology and Institute of Biomedical Science. Nikki has also been a Course Leader for several degree programs including the BSc/MSci in Biochemistry BSc/MSci Human Biology, BSc Cellular and Molecular Biosciences, BSc Biochemistry and Biotechnology degrees.
She is the Chair of the College of Health, Wellbeing and Life Sciences Biosciences Ï㽶ÊÓƵ Ethics Committee and has been a member of the University Ï㽶ÊÓƵ Ethics Committee for over 20 years. She works with both University and College members to implement and update ethical procedures and policies in the University.
Nikki is a member of the Biomolecular Sciences Ï㽶ÊÓƵ Centre (BMRC) and part of the Cancer and Tissue Engineer Ï㽶ÊÓƵ groups.
Cancer Ï㽶ÊÓƵ
Her cancer research focuses on the use of polyphenols in the treatment of cancer, and their impact on standard chemotherapy treatments, this work has lead to many national and international collaborations and number publications.
Other cancer research projects involve the synthesis of novel anti-cancer treatments with a number of collaborators including Dr. Neil Cross and Dr. Alice Johnson at SHU.
Tissue Engineering
Her regenerative medicine research focuses on the development of Novel 3D Cell culture systems for the study of gastrointestinal disease. This research is in collaboration with Prof Christine Le Maitre from Sheffield University and Prof Chris Sammon from MERI.
Further work into epithelial regenerative is also being undertaken in collaboration with Prof Christine Le Maitre from the BMRC and Prof Andrew Alderson from MERI and Prof Prasad Godbole at the Sheffield Children's Hospital.
Specialist areas of interest
Cancer cell biology/biochemistry and regenerative medicine and tissue engineering
Teaching
School of Biosciences and Chemistry
College of Health, Wellbeing and Life Sciences
Subject area
Bioscience and chemistry
Courses taught
BSc/MSci Biology
BSc/MSci Biochemistry
BSc/MSci Biomedical Sciences
BSc/MSci Biomedicine and Healthcare
Modules taught
Fundamentals of Biomedical Science
Human Reproduction and Endocrinology
Biochemistry and Genetics
Physiology of Health and Disease
BSc Ï㽶ÊÓƵ Projects
MSci Ï㽶ÊÓƵ Projects
Developing Professional Scientific Skills
Advanced Professional Scientific Skills
Advanced Laboratory Ï㽶ÊÓƵ Practice
Ï㽶ÊÓƵ
Current research projects
Cancer cell biology/biochemistry and regenerative medicine and tissue engineering
Ï㽶ÊÓƵ Collaborations
The use of polyphenols in the treatment of leukaemia and their impact on standard chemotherapy treatments. This work is in collaboration with Dr Gordon McDougall from the James Hutton Institute and members of the BMRC.
Other cancer research projects involve the study of metastasis formation research with Dr Nick Peake and Dr Neil Cross, and the modulation of the immune system in the treatment of cancer with Dr Rebecca Leyland.
Investigating the use of Novel 3D Cell culture method for the study and treatments of small intestinal inflammatory disease. This research is in collaboration with Prof Christine Le Maitre from the BMRC and Prof Chris Sammon from MERI. This collaboration has enabled a more materialistic approach to gastrointestinal research.
Epithelial regenerative medicine research. This research is in collaboration with Prof Christine Le Maitre from the BMRC and Prof Andrew Alderson from MERI and Prof Prasad Godbole.
Funding
Epithelial regenerative medicine research. This research is in collaboration with Prof Christine Le Maitre from the BMRC and Prof Andrew Alderson from MERI and Prof Prasad Godbole. Funded by Pioneer, SCH and SHU.
Cancer research collaborators include Dr Gordon McDougall from the James Hutton Institute and Dr Neil Cross, Dr Sarah Haywood-Small and Prof Christine Le Maitre from the BMRC. This work has been funded and sponsored by the Saudi Arabian Government.
Regenerative gastrointestinal medicine research is in collaboration with Prof Christine Le Maitre from the BMRC and Prof Chris Sammon from MERI. This work is funded and sponsored by the Iraqi Government.
Epithelial regenerative medicine research is in collaboration with Prof Christine Le Maitre from the BMRC, Prof Andrew Alderson form MERI and Prof Prasad Godbole from Sheffield Children's Hospital.
Publications
Key Publications
Dosh, R. (2018). . (Doctoral thesis). Supervised by Le Maitre, C.
Mahbub, A.A.-.H. (2015). . (Doctoral thesis). Supervised by Jordan-Mahy, N., Cross, N., Le Maitre, C., & Haywood-Small, S.
Journal articles
Hudson, K., Cross, N.A., Jordan-Mahy, N., & Leyland, R. (2022). Programmed death-ligand 1 expression in human cancer three-dimensional cell culture models. .
Mahbub, A.A., Le Maitre, C., Cross, N., & Jordan-Mahy, N. (2022). . Scientific Reports, 12 (1).
Alaswad, H., Mahbub, A., Le Maitre, C., & Jordan-Mahy, N. (2021). . International Journal of Molecular Sciences, 22 (6).
Hudson, K., Cross, N., Jordan-Mahy, N., & Leyland, R. (2020). . Frontiers in Immunology, 11, 568931.
Mardling, P., Alderson, A., Jordan-Mahy, N., & Le Maitre, C. (2020). . Biomaterials Science.
Dosh, R., Jordan-Mahy, N., Sammon, C., & Le Maitre, C.L. (2019). . Biomaterials Science, 7 (10), 4310-4324.
Mahbub, A.A., Le Maitre, C., Haywood-Small, S., Cross, N., & Jordan-Mahy, N. (2019). . Oncotarget, 10 (44).
Le Maitre, C.L., Dosh, R., Jordan-Mahy, N., & Sammon, C. (2019). . Oncotarget.
Dosh, R.H., Jordan-Mahy, N., Sammon, C., & Le Maitre, C.L. (2019). . Scientific reports, 9 (1), 1812.
Dosh, R., Jordan-Mahy, N., Sammon, C., & Le Maitre, C. (2018). . Tissue engineering. Part B, Reviews, 24 (2), 98-111.
Dosh, R., Essa, A., Jordan-Mahy, N., Sammon, C., & Le Maitre, C. (2017). . Acta biomaterialia.
Mahbub, A., Le Maitre, C., Haywood-Small, S., Cross, N., & Jordan-Mahy, N. (2017). . Oncotarget, 8 (62), 104877-104893.
Mahbub, A.A., Le Maitre, C.L., Haywood-Small, S.L., Cross, N.A., & Jordan-Mahy, N. (2015). . Cell Death and Disease, 6, e2028.
Mahbub, A.A., Le Maitre, C.L., Haywood-Small, S.L., Cross, N.A., & Jordan-Mahy, N. (2015). . Cell Death Discovery, 1 (15043), 1-12.
Dahlawi, H., Jordan-Mahy, N., Clench, M., McDougall, G.J., & Le Maitre, C. (2013). . Food Science and Nutrition, 1 (2), 196-208.
Mahbub, A.A., Le Maitre, C., Haywood-Small, S., McDougall, G.J., Cross, N., & Jordan-Mahy, N. (2013). . Anti-cancer agents in medicinal chemistry, 13 (10), 1601-1613.
Phillips, K., Jordan-Mahy, N., Nicklin, M.J.H., & Le Maitre, C. (2013). . Annals of the rheumatic diseases, 72 (11), 1860-7.
Dahlawi, H., Jordan-Mahy, N., Clench, M., & Le Maitre, C. (2012). . Nutrition and Cancer, 64 (1), 100-110.
McDougall, G.J., Dobson, P., & Jordan-Mahy, N. (2010). . Food chemistry, 119 (2), 758-764.
N'Dow, J., Jordan, N., Robson, C.N., Neal, D.E., & Pearson, J.P. (2005). The bladder does not appear to have a dynamic secreted continuous mucous gel layer. The Journal of urology, 173 (6), 2025-2031.
Sherwood, P.V., Wibawa, J.I.D., Atherton, J.C., Jordan, N., Jenkins, D., Barrett, D.A., ... Spiller, R.C. (2002). Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats. Gut, 51 (4), 490-495.
Newton, J.L., Jordan, N., Pearson, J., Williams, G.V., Allen, A., & James, O.F. (2000). The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori. Gerontology, 46 (3), 153-157.
Newton, J.L., Jordan, N., Oliver, L., Strugala, V., Pearson, J., James, O.F., & Allen, A. (1998). Helicobacter pylori in vivo causes structural changes in the adherent gastric mucus layer but barrier thickness is not compromised. Gut, 43 (4), 470-475.
Jordan, N., Newton, J., Pearson, J., & Allen, A. (1998). A novel method for the visualization of the in situ mucus layer in rat and man. Clinical science (London, England : 1979), 95 (1), 97-106.
JORDAN, N., NEWTON, J., PEARSON, J., & ALLEN, A. (1998). A novel method for the visualization of the in situ mucus layer in rat and man. Clinical Science, 95 (1), 97-106.
Strugala, V., Jordan, N., Pearson, J.P., & Allen, A. (1998). The colonic mucus barrier and changes in inflammatory bowel disease. Gastroenterology, 114, A1092.
Allen, A., Newton, J., Oliver, L., Jordan, N., Strugala, V., Pearson, J.P., & Dettmar, P.W. (1997). Mucus and H. pylori. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 48 (3), 297-305.
Oliver, L., Newton, J.L., Jordan, N., Goddard, P., Dettmar, P., Pearson, J.P., & Allen, A. (1997). Effects of Helicobacter pylori colonisation on the adherent gastric mucus barrier. Biochemical Society transactions, 25 (2), 372S.
Newton, J., Jordan, N., Williams, G., Allen, A., James, O., & Newton, J. (1997). Thinning of the Gastric Mucus Gel Layer in H Pylori Positive Subjects with Advancing Age. Age and Ageing, 26 (suppl 3), P8.
Conference papers
Hudson, K., Cross, N., Jordan-Mahy, N., & Leyland, R. (2021). Characterization of 3D models of human breast, prostate and colorectal cancer. CANCER RESEARCH, 81 (13).
Dahlawi, H., Jordan-Mahy, N., & Le Maitre, C. (2015). Antiproliferative and induction of apoptosis by pomegranate's anthocyanidins (delphinidin, cyanidin and pelargonidin) on lymphoid and myelopid leukaemia cell lines. BRITISH JOURNAL OF HAEMATOLOGY, 169, 72-73.
Mahbub, A., Le Maitre, C., Haywood-Small, S.L., McDougall, G., Cross, N.A., & Jordan-Mahy, N. (2012). The Anti-cancerous Potential of Polyphenols in the Treatment of Human Myeloid and Lymphoid Leukaemia. JOURNAL OF PATHOLOGY, 228, S34.
Dahlawi, H., Jordan-Mahy, N., Clench, M.R., McDougall, G.J., & Le Maitre, C. (2012). Impact of Anthocyanin Chemical Structure Found in Pomegranate Juice on Leukaemia Treatment. JOURNAL OF PATHOLOGY, 228, S37.
Wilson, A., Jordan-Mahy, N., Haywood-Small, S., Cross, N.A., & Le Maitre, C. (2012). Extracts From Red and White Cabbage Contains Bio-Active Compounds Which Induce Apoptosis in Myeloid and Lymphoid Leukaemia Cell Lines. JOURNAL OF PATHOLOGY, 228, S37.
Stanley, K.N., Cabry, S.H., Dalton, C.F., & Jordan-Mahy, N. (2007). Use of mucin-overproducing cell line HT29-MTX to study the interaction between Campylobacter jejuni and commensal micro-organisms at the mucin interface of the gastrointestinal tract. ZOONOSES AND PUBLIC HEALTH, 54, 102.
Theses / Dissertations
Alaswad, H. (2024). The Molecular Action of Polyphenols in Leukeamia. (Doctoral thesis). Supervised by Jordan-Mahy, N.
Alzufairi, A.A. (2024). . (Doctoral thesis). Supervised by Cross, N., & Jordan-Mahy, N.
Alaswad, H.A. (2024). . (Doctoral thesis). Supervised by Jordan-Mahy, N., Le Maitre, C., & Mahbub, A.
Alzufairi, A. (2024). The Induction of Ferroptosis's in 3D Models of Breast Cancer. (Doctoral thesis). Supervised by Jordan-Mahy, N., & Cross, N.
Hudson, K.V. (2023). . (Doctoral thesis). Supervised by Leyland, R., Cross, N., & Jordan-Mahy, N.
Hudson, K.V. (2023). . (Doctoral thesis). Supervised by Leyland, R., Cross, N., & Jordan-Mahy, N.
Dahlawi, H. (2013). . (Doctoral thesis). Supervised by Le Maitre, C., & Jordan-Mahy, N.
Posters
Hudson, K., Cross, N., Jordan-Mahy, N., & Leyland, R. (2021). . Presented at: British Society for Immunology Congress 2021, Edinburgh, UK, 2021
Hudson, K., Cross, N., Jordan-Mahy, N., & Leyland, R. (2020). . Presented at: EACR-AACR-ASPIC Conference: Tumour Microenvironment, Lisbon, Portugal, 2020
Hudson, K., Jordan-Mahy, N., Cross, N., & Leyland, R. (2019). . Presented at: BACR: Tumour Microenvironment meeting, Nottingham, UK, 2019
Hudson, K., Cross, N., Jordan-mahy, N., & Leyland, R. (2018). . Presented at: BMRC/MERI Winter Poster Event, Sheffield, 2018
Owens, K., Peake, N., Jordan-Mahy, N., & Leyland, R. (2018). . Presented at: British Society for Immunology: Yorkshire Immunology Group Annual Symposium 2018, University of York, UK, 2018
Other activities
External examiner for Leeds Beckett University
Postgraduate supervision
Recent PhD Thesis
Alzufairi A. A. (2023) Enhancement of Breast Cancer Chemotherapy and Radiotherapy Responses by Modulation of Ferroptosis (Doctoral thesis). Supervised by Cross N. A., and Jordan-Mahy, N.
Alaswad H. A. (2023) Molecular Mechanisms of Action of Polyphenols and Polyacetylenes in Leukaemia Cell Lines (Doctoral thesis). Supervised by Le Maitre, C. L., and Jordan-Mahy, N.
Hudson, KV. (2023). Investigating the Intrinsic Role of Programmed Death-Ligand 1 in Human Cancers. (Doctoral thesis). Supervised by Leyland, R., Cross, N. A., and Jordan-Mahy, N. https://doi.org/10.7190/shu-thesis-00520
Dosh, R. (2018). Developing models of the small intestine. (Doctoral thesis). Supervised by Le Maitre, C. https://doi.org/10.7190/shu-thesis-00131 Supervised by Le Maitre, C. L., and Jordan-Mahy, N.
Mahbub, A. A. (2015). The anti-cancer potential of polyphenols in the treatment of leukaemia. (Doctoral thesis). Supervised by Jordan-Mahy, N., Cross, N., Le Maitre, C., and Haywood-Small, S. Supervised by Le Maitre, C. L., Cross N. A., and Jordan-Mahy, N.
Dahlawi, H. (2013). Effect of pomegranate extracts on apoptosis and cell cycle in haematological malignancies. (Doctoral thesis). Supervised by Le Maitre, C., and Jordan-Mahy, N.
Previous supervision:
Development of tissue engineering models for epithelia tissues
The development of novel 3D cell culture models for the investigation of inflammatory bowel disease
The anti-cancer potential of polyphenols in the treatment of leukaemia
The anti-cancer potential of pomegranate juice extract in the treatment of leukaemia
The adherent colonic mucin layer